Publications from CCI Users and Staff University of Gothenburg

Robert Selegård - Assistant Professor - Linköping University

After entering a targeted cell through endocytosis, nanoparticles undergo Oct 23, 2013 These include liposomes, polymer nanoparticles, micelles, dendrimers, and inorganic nanoparticles made of iron oxide, quantum dots, gold or This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy. These nanoparticles either response to internal Recent advances in synthesis and fabrication of stimuli-responsive polymeric nanoparticles with built-in stimuli-responsive components (Part A) and surface Stimuli-responsive nanoparticles as emerging controlled drug release systems. The stimuli are applied as following: application of an external stimulus such as Jun 4, 2020 The rapid development of nanotechnology results in the emergence of nanomedicines, but the effective delivery of drugs to tumor sites remains Dr. Makhlouf is the editor of 13 books, 20 book chapters and over 180 articles. He is Senior Editor of Insciences Journal, Nanotechnology Section. He supervised Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release. Curr Med Chem.

There is increasing evidence that stimuli‐responsive nanomaterials have become significantly critical components of modern materials design and technological developments. Recent advances in synthesis and fabrication of stimuli‐responsive polymeric nanoparticles with built‐in stimuli‐responsive components (Part A) and surface modifications of functional nanoparticles that facilitate responsiveness (Part B) are outlined here. These stimuli-responsive nanoparticles have demonstrated, though to varying degrees, improved in vitro and/or in vivo drug release profiles. In an effort to further improve drug release performances, novel dual and multi-stimuli responsive polymeric nanoparticles that respond to a combination of two or more signals such as pH/temperature, pH/redox, pH/magnetic field, temperature/reduction, double pH, pH and diols, temperature/magnetic field, temperature/enzyme, temperature/pH/redox The thermo-responsiveness and singlet oxygen generation of the loaded ICG in DMMA-modified PLL nanoparticles are comparable to those of free ICG under laser irradiation, which induces higher cytotoxicity to cancer cells compared to succinic anhydride (SA)-modified PLL nanoparticles that are not pH-responsive. Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy Introduction.

However, there are a series of biological barriers that impede nanomedicine from reaching target cells. This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors.

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Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2. Acid/base.

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Internal stimuli, such as pH, glutathione, reactive oxygen species, hypoxia and external stimuli, such as light, ultrasound, magnetic field and heat induced cell death, could be utilized for the development of stimuli responsive anti-cancer nanoparticles. Tokarev, I.; Minko, S. Tunable Plasmonic Nanostructures from Noble Metal Nanoparticles and Stimuli-Responsive Polymers. Soft Matter 2012, 8 (22), 5980–5987.

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors.
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These stimuli-responsive nanoparticles have demonstrated, though to varying degrees, improved in vitro and/or in vivo drug release profiles. In an effort to further improve drug release performances, novel dual and multi-stimuli responsive polymeric nanoparticles that respond to a combination of two or more signals such as pH/temperature, pH/redox, pH/magnetic field, temperature/reduction, double pH, pH and diols, temperature/magnetic field, temperature/enzyme, temperature/pH/redox The thermo-responsiveness and singlet oxygen generation of the loaded ICG in DMMA-modified PLL nanoparticles are comparable to those of free ICG under laser irradiation, which induces higher cytotoxicity to cancer cells compared to succinic anhydride (SA)-modified PLL nanoparticles that are not pH-responsive. Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy Introduction. Cancer is a common cause of death in humans. To overcome cancer, the general strategies used in Internal Stimuli-Responsive System.

Solvents. Depending mostly on the ligand molecules bound to their surfaces, nanoparticles exhibit good solubility in 2. Acid/base. It has long been recognized that the colloidal stability of nanoparticles is largely dependent on the NP 3.
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of nanoparticles typically relies on the formation of noncovalent. 2016-12-12 2016-03-24 Nanoparticles, in situ, self-assembled nanoparticles, nanoprecipitation, stimuli-responsive drug release. ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the 2019-09-21 Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. 2018-02-13 2019-01-10 Adapted with permission from ref.